Esra Tasali, M.D. is an internationally recognized expert in the study of sleep disturbances as they relate to metabolic diseases. She has made important contributions to our understanding of the mechanistic pathways linking reduced sleep duration and quality to increased risk of diabetes and obesity. Her innovative research has demonstrated that experimental reductions in sleep quality adversely affects glucose homeostasis and may increase the risk for diabetes. Her work also demonstrated that sleep duration is an important regulator of neuroendocrine hormones and energy metabolism in peripheral tissues. Additionally, Dr.Tasali’s studies examine how the experimental laboratory findings could be translated into clinical practice in individuals with insufficient sleep and sleep disorders such as sleep apnea. Her work has significantly contributed to our understanding of the links between sleep apnea and glucose metabolism. She has also demonstrated that healthy sleep habits can be successfully implemented in real life settings. Over the past decade, she has led as a principal investigator multidisciplinary research projects funded by the National Institute of Health to investigate the effects of sleep and sleep disorders on metabolic function.

  1. Broussard J, Ehrmann D, Van Cauter E, Tasali E*, Brady M*. Impaired Insulin Signaling in Human Adipocytes Following Experimental Sleep Restriction the Adipocyte. Annals of Internal Medicine, 2012; 157(8): 549-57 (*co-senior authors). PMID: 23070488
  2. Tasali E, Chapotot F, Wroblewski K, Schoeller D. The Effects of Extended Bedtimes on Sleep Duration and Food Desire Extension in Overweight Young Adults: A Home-Based Intervention. Appetite, 2014; 80:220-4. PMID: 24858836
  3. Broussard J, Chapotot F, Abraham V, Day A, Delebecque F, Whitmore H, Tasali E. Sleep Restriction Increases Free Fatty Acids in Healthy Men. Diabetologia, 2015, Feb 22 (Epub). PMID: 25702040
  4. Pamidi S, Wroblewski K, Stepien M, Sharif-Sidi K, Kilkus J, Whitmore H, Tasali E. Eight Hours of Nightly CPAP Treatment of Obstructive Sleep Apnea Improves Glucose Metabolism in Prediabetes: A Randomized Controlled Trial. Am J Respir Crit Care Med, 2015.192(1):96-105. PMID: 25897569
  5. Broussard J, Kilkus J, Delebecque F, Abraham V, Day A, Whitmore H, Tasali E. Elevated Ghrelin Predicts Food Intake During Experimental Sleep Restriction. Obesity, 2016. 24:132-138. PMID: 26467988
 
 

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    Institute for Integrative Physiology

    The University Of Chicago
    Geri Harges
    Administrative Specialist
    5841 South Maryland Avenue
    Chicago, Illinois 60637
    773-834-5254
    Email: gharges1@medicine.bsd.uchicago.edu