Research Interests:

Dr. Nickolai Dulin studies the signaling mechanisms of myofibroblast differentiation as related to the pathogenesis of pulmonary fibrosis. This includes the signaling induced by TGF-beta and by G protein coupled receptors, control of cell signaling by actin and microtubule sytoskeleton, activation of mechanosensitive transcription factors and identification of their target genes, and control of these processes through protein phosphorylation. His studies using cultured human lung fibroblasts and animal models of pulmonary fibrosis aim to identify new signaling molecules that could be targeted for potential treatment of this disease.

 

Recent Publications:

Sandbo N, Ngam C, Torr E, Kregel S, Kach J, Dulin NO. Control of myofibroblast differentiation by microtubule dynamics through a regulated localization of mDia2. J Biol Chem. 2013, 288(22):15466-73.

Kach J, Sandbo N, Reed B, La J, Tian X, Brain S, Krishnan R, Birukov KG, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol  2013, 304(11):L757-64.

Kach J, Sandbo N, La J, Denner D, Reed EB, Akimova OA, Koltsova S, Orlov SN, Dulin NO. Antifibrotic Effects of Noscapine Through Activation of Prostaglandin E2 Receptors and Protein Kinase A. J Biol Chem. 2014; 289(11):7505-13.

La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Mutlu GM, Orlov SN, Dulin NO . Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 May 1;310(9):L815-23. PMID: 26851261.

 

La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Mutlu GM, Orlov SN, Dulin NO. Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 2016 Dec 22;11(12):e0168363.  PMID: 28006004.

 

 
 

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Contact Information

    Institute for Integrative Physiology

    The University Of Chicago
    Geri Harges
    Administrative Specialist
    5841 South Maryland Avenue
    Chicago, Illinois 60637
    773-834-5254
    Email: gharges1@medicine.bsd.uchicago.edu