Major research areas in the current membership of the Institute for Integrative Physiology falls into 4 major categories.

Cardio-Respiratory Physiology


Section Head:

Major Research Area:

  • Catecholamine secretion
  • Nicotinic cholinergic receptors
  • Pain & nociception
  • Respiratory physiology

Members

Major Research & Training Programs:

  • CTSA, a major program at the Pritzker School of Medicine (PI: Dr. Julian Solway)
  • Institutional training program (T32) entitled “Training in Pulmonary Physiology & Medicine” (PI: Dr. Julian Solway)
  • Institutional training program (T32) Entitled “Training in Neurobiology” (PI: Dr. Daniel McGehee)

Membrane Physiology


Section Head:

Major Research Area:

  • Structure and conformational dynamics or ion channels and transporters
  • Mechanistic basis of voltage sensing in excitable systems
  • Modulation of ion channel behavior by protein modification
  • Molecular basis of gating the K+ channel selectivity filter
  • Structural basis of ion channel modulation by O2 & reactive oxygen species
  • Gating and selectivity in Na+ channels

Members

Major Research & Training Programs:

  • “The Membrane Protein Structural Dynamic Consortium” (NIGMS), 23 Pis, 14 participating institutions in 4 countries (PI: Dr. Eduardo Perozo)

O2 Physiology


Section Head:

Major Research Area:

  • Mechanisms of O2 sensing
  • Gaso transmitters in O2 sensing
  • Hypoxia and neurotransmitter metabolism
  • Reactive oxygen species and hypoxia
  • Intermittent hypoxia and sleep-disordered breathing
  • Hypoxia-inducible factors (HIFs) in physiology & pathology
  • Ca2+ and K+ channels & hypoxia
  • Epigenetic regulation by neonatal hypoxia-inducible
  • Autonomic consequences of intermittent hypoxia

Members

Major Research & Training Programs:

  • Program Project Grant (PO1-HL-090554) “Integrative Consequences of Hypoxia” (P.I. Nanduri R. Prabhakar)
  • Institutional Training Grant (T32 HL-94282) “Training in O2 Biology in Health
    and Disease” (P.I. Nanduri R. Prabhakar)
 
 

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Contact Information

    Institute for Integrative Physiology

    The University Of Chicago
    Geri Harges
    Administrative Specialist
    5841 South Maryland Avenue
    Chicago, Illinois 60637
    773-834-5254
    Email: gharges1@medicine.bsd.uchicago.edu