Shakil Khan, Ph.D.

Research Professional Department of Medicine
Work 5841 S. Maryland Ave MC 5068, Office: N-603 Chicago, IL 60637 Work Phone: 773.834.0690 Work Fax: 773.834.5252
Photo of Shakil Khan, Ph.D.

Biographical Info

Research Interest

My research focusses on studying the mechanisms by which Intermittent Hypoxia inhibits Mitochondrial complex I activity. The study reveals three novel findings: (i) IH-evoked mitochondrial complex I inhibition requires Reactive Oxygen Species generation by NADPH Oxidase 2 and Ca2+-dependent S-glutathionylation of complex I subunits, (ii) inhibition of complex I increases mitochondrial ROS, and (iii) mitochondrial ROS contributes to sustained but not transient elevations in blood pressure in IH-treated rats.

Featured Publications

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  • Ph.D., Aligarh Muslim University, Aligarh, India
Categories: Member