Ying-Jie Peng, Ph.D. » Members

Biographical Info

Research Interest

Patients with sleep apnea experience chronic intermittent hypoxia during sleep display overactive sympathetic nerve activity and abnormalities in breathing and are at high risk of developing hypertension. The carotid body is the primary sensory organ that detects changes in O2 levels in arterial blood, and the ensuing chemosensory reflex is a potent regulator of autonomic functions. My research focuses on understanding the mechanisms underlying O2 sensing by the carotid body and assessing the role of carotid bodies in mediating cardiorespiratory responses to simulated apneas in rodent models.

Featured Publications

• H₂S Mediates carotid body response to hypoxia but not anoxia
• Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model
• Measurement of Sensory Nerve Activity from the Carotid Body
• Complementary roles of gasotransmitters CO and H2S in sleep apnea
• H2S Production by Reactive Oxygen Species in the Carotid Body Triggers Hypertension in a Rodent Model of Sleep Apnea
• CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia

Training

• Ph.D., Shanghai Medical University, China, Physiology