Institute for Integrative Physiology

Major research areas in the current membership of the Institute for Integrative Physiology falls into 3 major categories.

Cardio-Respiratory Physiology

Section Head:

• Gokhan M. Mutlu, M.D..

Major Research Area:

• Catecholamine secretion
• Nicotinic cholinergic receptors
• Pain & nociception
• Respiratory physiology

Members

• Nickolai Dulin, Ph.D.
• Yun Fang, Ph.D.
• Aaron Fox, Ph.D.
• Robert Hamanaka, Ph.D.
• Peggy Mason, Ph.D.
• Daniel McGehee, Ph.D.
• Willard Sharp, M.D., Ph.D.
• Julian Solway, M.D.
• Esra Tasali, M.D.

Major Research & Training Programs:

      CTSA, a major program at the Pritzker School of Medicine (PI: Dr. Julian Solway) 

      Institutional training program (T32) entitled ΓÇ£Training in Pulmonary Physiology &       

      MedicineΓÇ¥ (PI: Dr. Julian Solway)

      Institutional training program (T32) Entitled ΓÇ£Training in NeurobiologyΓÇ¥ (PI: Dr. Daniel

      McGehee)

Membrane Physiology

Section Head:

• Francisco Bezanilla, Ph.D.

Major Research Area:

• Structure and conformational dynamics or ion channels and transporters
• Mechanistic basis of voltage sensing in excitable systems
• Modulation of ion channel behavior by protein modification
• Molecular basis of gating the K+ channel selectivity filter
• Structural basis of ion channel modulation by O2 & reactive oxygen species
• Gating and selectivity in Na+ channels

Members

• Benoit Roux, Ph.D.
• William N. Green, Ph.D.
• Dorothy A. Hanck, Ph.D.
• Deborah J. Nelson, Ph.D.
• Eduardo Perozo, Ph.D.

Major Research & Training Programs:

     The Membrane Protein Structural Dynamic ConsortiumΓÇ¥ (NIGMS), 23 Pis, 14 participating 

      institutions in 4 countries (PI: Dr. Eduardo Perozo)

O2 Physiology

Section Head:

• Nanduri R. Prabhakar, Ph.D., D.Sc.

Major Research Area:

• Mechanisms of O2 sensing
• Gaso transmitters in O2 sensing
• Hypoxia and neurotransmitter metabolism
• Reactive oxygen species and hypoxia
• Intermittent hypoxia and sleep-disordered breathing
• Hypoxia-inducible factors (HIFs) in physiology & pathology
• Ca2+ and K+ channels & hypoxia
• Epigenetic regulation by neonatal hypoxia-inducible
• Autonomic consequences of intermittent hypoxia

Members

• Nanduri R. Prabhakar, Ph.D., D.Sc.
• Alfredo Garcia, Ph.D.
• Lucy Ann Godley, M.D., Ph.D.
• Anna Gridina, M.D., Ph.D.
• Jayasri Nanduri, Ph.D.
• Ying-Ji Peng, Ph.D.
• Shakil Khan, Ph.D.
• Xiuli Zhang, Ph.D.
• Xiaoyu Su, Ph.D.

Major Research & Training Programs:

    Program Project Grant (PO1-HL-090554) “Integrative Consequences of Hypoxia” (P.I.     

    Nanduri R. Prabhakar)